Lake Nona Medical City Vacation Packages
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Top Holiday Package Deals in Lake Nona Medical City
Price found within the past 48 hours. Click for updated prices.
The Delaney Hotel
South Orange
CA $1,013
per person
Oct 20 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Hamilton (YHM) to Orlando (MCO)
9.6/10 Exceptional! (1,178 reviews)
We had a great stay at this hotel. The room was clean, comfortable, and well maintained, and the staff was friendly and welcoming. The location was also very convenient, making it easy to get around and enjoy the area.
Overall, it was a very pleasant experience and a good value for the price. I would definitely recommend this hotel and would be happy to stay here again.
Reviewed on Aug 7, 2026
Where to stay in Lake Nona Medical City
Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City
Bay Lake
4 out of top 10 points of interest in this area
Home to all four Walt Disney World Resort theme parks and one water park, this city offers endless entertainment, including Disney's Fort Wilderness Resort & Campground and Magnolia and Palm Golf Courses.
International Drive District
Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.
Reunion
The waterparks and pristine golf courses are top of the list for many visitors to Reunion. A stop by Reunion Resort Golf Course or Jack Nicklaus Course might round out your trip.
Florida Center
2 out of top 10 points of interest in this area
While visiting Florida Center, you might make a stop by sights like Universal Orlando Resort and Universal Studios Florida.
Champions Gate
Abundant dining options and pristine golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.
Lake Nona Medical City Hotel Deals
DoubleTree by Hilton at the Entrance to Universal Orlando
5780 Major Blvd Orlando FL
Fully refundable
CA $109
CA $123 total
Sep 1 - Sep 2
includes taxes & fees
8.6/10 Excellent! (7,023 reviews)
"Good service"
Reviewed on Aug 9, 2026
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
8800 Vistana Centre Dr Orlando FL
Fully refundableReserve now, pay when you stay
CA $172
CA $193 total
Sep 7 - Sep 8
includes taxes & fees
Rosen Inn Lake Buena Vista
8442 Palm Parkway Orlando FL
Fully refundableReserve now, pay when you stay
CA $100
CA $113 total
Aug 11 - Aug 12
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Lake Nona Medical City vacation package cost?
The cheapest Lake Nona Medical City package is CA $574, so your dream trip can become a reality — without burning a hole in your pocket. Combine flights, hotels and car rentals to tailor make a package that suits your travel style.
How do I get a cheap travel package to Lake Nona Medical City?
Find flights that fit your busy schedule, add a hotel to your booking and watch the savings rack up with a Lake Nona Medical City vacation package. It's as easy as that! From flights and hotels to tours and rental cars, Expedia makes traveling cheap and easy. And with more than 550 air carriers and 1,000,000 hotel options globally to pick from, you won't be short of choice.
Where should I stay in Lake Nona Medical City?
With loads to explore in Lake Nona Medical City, it'd be convenient for you to stay close to its attractions. Nemours Childrens Hospital, VA Medical Center at Lake Nona and University of Central Florida College of Medicine are some fascinating ones to add to your to-do list.
What are the top hotels in Lake Nona Medical City?
Make a reservation at Residence Inn Orlando Lake Nona. It's one of the area's most sought-after properties. Another reputable option in Lake Nona Medical City is Courtyard Orlando Lake Nona.
How far in advance should I book my Lake Nona Medical City vacation?
It depends on the airline, but you can generally look up international fares on Expedia up to a year in advance. While it's generally a good idea to book ahead of time, lucky customers occasionally score a cheaper ticket just weeks prior to the date of departure.
What does an Expedia Lake Nona Medical City travel package include?
Expedia has everything you need to organize your Lake Nona Medical City getaway, but what goes into your package is totally up to you. Choose from a combination of hotels, rental cars and flights. In search of some experiences or tours to keep you busy? Once you've made your booking, you can add them too. Whatever your budget or style, there's a deal to match your needs.
What should I know before booking a Lake Nona Medical City travel package?
Locking in all the parts of your escape together is a great way to save. Combine your airfares, rental cars and hotels into one package. But hotels aren't your only option. Expedia has all types of properties, including vacation rentals like beachside villas and city apartments. The list goes on!
Can I choose my airline with a Lake Nona Medical City Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines worldwide. Our vacation packages give you the freedom to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my Lake Nona Medical City vacation package?
Don't worry if you're rethinking your Lake Nona Medical City vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it at no cost. However, bookings made more than 24 hours ago may incur a fee from your airline, hotel or car rental company. We know life can throw the occasional spanner in the works, so look up our Customer Service Portal if that occurs. When you're ready to make changes, we'll be here to help.
Things to do
Universal Orlando Resort Theme Park Tickets (US & Canada)
CA $229
per adult
86% of travellers recommend
90 Minute Open Jump at a Trampoline Park in Kissimmee
CA $32
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.